Schreiber Lab

Humboldt University of Berlin

Berlin (DE3) · Germany

ERC-funded
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ERC Consolidator Grant · 2019

A new type of spike: Homoclinic spike generation in cells and networks

Action potentials are not all equal. Despite shared biophysical principles and even similar action-potential shape, neurons with different spike generators can encode vastly different aspects of a stimulus and result in radically different behaviors of the embedding network. Differences between spike generators may be hard to discern because the information content of a spike train is not obvious to the naked eye. This is where computational analysis comes into play: theoretical research has shown that spike generation can be classified into a few dynamical types with qualitatively distinct computational properties. Among these, so-called homoclinic spikes – unlike the other commonly…

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