Kohl Lab

Francis Crick Institute

- · United Kingdom

ERC-funded
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ERC Starting Grant · 2019

Neural adaptations during pregnancy

An expectant mother’s brain undergoes dramatic structural remodeling during pregnancy. These changes are thought to be elicited by hormones, orchestrating the behavioural and physiological adaptations necessary for infant care. Despite the scale of these effects, we know little about the neural mechanisms by which pregnancy affects the brain. Recent methodological advances now offer the exciting opportunity to address these questions. This project will use a multidisciplinary approach to uncover the molecular, cellular and circuit-level mechanisms of pregnancy hormone action in a mouse model. We will first focus on which aspects of parenting, feeding and aggression are affected by pregnancy…

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