ERC Advanced Grant · 2020
E Pluribus Unum: Principles and Plasticity of Electrical Coupling in a Neuronal Network
The complex network activity patterns of the CNS result from an interplay between intrinsic neuronal properties and the connections formed by component cells. Connectivity is most commonly considered in terms of the classical chemical synapse. It is now clear, however, that electrical synapses formed by intercellular connexin channels in gap junctions (GJs) are widespread in the mammalian CNS and critically influence circuit activity. But exactly how GJs shape brain output, and how electrical coupling is regulated over different time-scales remains elusive. In the proposed project, we will take advantage of a recently discovered species difference between hypothalamic tuberoinfundibular…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.