ERC Advanced Grant · 2020
Synaptic Promiscuity in Brain Development
Precise synaptic connectivity is a prerequisite for the function of neural circuits, yet individual neurons, taken out of their developmental context, readily form unspecific synapses. The goal of this proposal is to understand the roles and requirements of such promiscuous synapse formation during brain development. The observation of promiscuous synapse formation is not at odds with precise outcomes. The developmental program can ensure correct partnerships between neurons that form synapses promiscuously, but to what degree remains largely unresolved. My group has developed live imaging and optogenetic manipulations of dynamic synaptic choice processes in the intact developing fly brain.…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.