ERC Starting Grant · 2020
The identification of numerous genetic forms of Parkinson's disease (PD) has highlighted the importance of mitochondrial and lysosomal pathways in disease pathogenesis. In my recent work, I discovered that oxidized dopamine (DA) and alpha-synuclein serve as key mediators of mitochondrial and lysosomal dysfunction in midbrain DA neurons that preferentially degenerate in PD. It has been well established that cytosolic DA oxidizes to reactive quinones and accumulates in neuromelanin in midbrain neurons, but my data demonstrated that the process of DA oxidation was dramatically increased in disease. Importantly, oxidized DA was detected only in iPSC-derived DA neurons from familial and sporadic…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.