Leroy Lab

Spanish National Research Council (CSIC)

Comunidad de Madrid (ES3) · Spain

ERC-funded
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ERC Starting Grant · 2020

Top down regulation of motivated behaviors by lateral septal integration of cortico-hippocampal inputs

How does cognition regulate innate “low-level” behaviors? While the cognitive functions of the prefrontal cortex (PFC) and hippocampus have been extensively studied, we know much less about their ability to regulate the activity of the various hypothalamic nuclei controlling motivated behaviors (sociability, aggression, mating, feeding). Living in society nonetheless requires that our past experiences and decision-making exert some degree of control over our “basic” behaviors. The lateral septum (LS) -receiving inputs from PFC and hippocampus and projecting primarily to the hypothalamus- is ideally positioned to integrate cognitive information and, in turn, regulate motivated behaviors.…

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