ERC Starting Grant · 2020
Decoding spatio-temporal omics in progressive neuroinflammation
Multiple sclerosis (MS) is a paradigmatic progressive neuroinflammatory disease characterized by multiple lesions across the entire central nervous system including both gray and white matter areas. Deconvoluting the spatio-temporal cellular and molecular landscape is therefore key to understanding underlying disease mechanisms and to develop cell-type specific therapies. The DecOmPress proposal is about integrative human and mouse single-cell genomic strategies to track-down reactive cellular states in compartmentalized progressive neuroinflammation. DecOmPress has two major research tracks (RTs). RT1 is an MS tissue discovery pipeline utilizing single-nucleus RNA and open chromatin…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.