Moser Lab

Medical Center Goettingen

Niedersachsen (DE9) · Germany

ERC-funded
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ERC Advanced Grant · 2021

Solving the dynamic range problem of hearing: deciphering and harnessing cochlear mechanisms of sound intensity coding

Our sense of hearing processes stimuli that differ in sound pressure by more than six orders of magnitude. Yet, while the presynaptic inner hair cells (IHCs) cover this wide dynamic range, each postsynaptic spiral ganglion neuron (SGN) encodes only a fraction and the intensity information is then reconstructed by the brain. This so-called “dynamic range problem” of hearing is known for decades, but how sound intensity information is decomposed into different neural pathways remains elusive. In vivo recordings report major functional SGN diversity and ensembles of such diverse neurons collectively encode intensity for a given sound frequency. Recently, a major heterogeneity of afferent SGN…

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