ERC Advanced Grant · 2021
Pain is a large societal and health problem. Although often thought of as an invariant representation of active nociceptors, pain varies a lot under the influence of different mental states, sometimes with near complete analgesia. Such modulation of pain is thought to occur through a descending pathway originating in the brain and to be executed by Rostral Ventromedial Medulla (RVM) neurons that project to the spinal cord. Deciphering the complexity of the cell types involved and how they contribute to the descending control of pain has been challenging, but recent advances in single-cell omics, computational biology and advanced genetic technologies now open for unbiased system-wide…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.