Novarino Lab

Institute of Science and Technology Austria

Ostösterreich (AT1) · Austria

ERC-funded
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Research focus

ERC Consolidator Grant · 2021

Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders

Since the ancient Egyptians, the fluid in the brain has been considered a product of spirits, a pathological signature or inert liquid. Even at the turn of the 19th century, when the cerebrospinal fluid (CSF) was first described as a physiological substance, the CSF and the interstitial fluid (ISF), the fluid surrounding all the cells of the brain, were considered solely as a cushion. Only more recently studies have begun to show that the compositions of these fluids can have a marked impact on brain development and animal behaviour. A number of studies have employed omics to demonstrate that the ISF and the CSF are rich in secreted proteins, RNAs and metabolites. However, it is still…

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