Bonev Lab

Research focus

ERC Consolidator Grant · 2021

Deciphering the Regulatory Logic of Cortical Development

The mammalian cortex is the most complex region of the brain responsible for higher cognitive functions. Abnormal cortical development often translates into prominent neuropsychiatric diseases, which affect different neuronal subtypes with unique molecular and morphological features. Increasing evidence suggests that epigenetic regulation is essential for cortical development but how multiple regulatory layers are coordinated to specify distinct neuronal lineages in vivo remains unclear. My team and I recently applied single-cell RNA-seq, single-cell ATAC-seq together with cell-type-specific DNA methylation and 3D genome measurements to map the regulatory landscape of neural differentiation…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.