ERC Starting Grant · 2021
Deciphering the microglia-neuron interactions in human Alzheimer's disease
The goal of this project is to decipher the exact cellular and molecular mechanisms by which human microglia transduce toxicity to neurons in Alzheimer's disease (AD). Genetics revealed that microglia are one of the central players in the pathogenesis of AD. I and others have characterized the phenotypic response of microglia in AD using transcriptomic and epigenetic tools. Nevertheless, it is yet to be defined how microglia communicate with other cells in the brain, by which mechanism they lead to neuronal alterations, and what the particular role of different microglial activation states is in this process. I will investigate the two major functional outputs of microglia - namely physical…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.