ERC Starting Grant · 2021
Radial Glia as Neurodevelopmental Mediators Of Gut Microbiota Signals
Increasing evidence points to the importance of gut microbiota in the aetiology of neurodevelopmental and neuropsychiatric conditions. However, the mechanisms and conduits through which microbiota influences brain development in the critical perinatal period, potentially leading to cognitive deficits in later life, remain largely unknown. My hypothesis is that the dynamic early-life gut microbiota modulates the primary brain neural stem cells, the radial glia (RG), thereby sculpting the concurrently maturing neurodevelopmental trajectory. RG are in direct contact with cerebrospinal fluid (CSF), whose composition relies on a functional blood-CSF barrier (BCSFB) at the choroid plexus.…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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