ERC Advanced Grant · 2022
The synaptic active zone as a signaling hub for sleep homeostasis and resilience
Resilience designates the ability of the brain to cope with and adapt to stressful situations. Sleep homeostasis is tightly linked to resilience, and the sleep deficits observed alongside neurodegeneration probably operate as direct “drivers” of neurodegeneration. However, the knowledge gaps still remain huge and causally bridging the molecular/cellular with the behavioral and organismic level remains a challenge, hampering progress equally for biomedical and basic research. Our recent data suggest that a form of presynaptic active zone plasticity (“PreScale”), widely triggered in sleep-deprived Drosophila brains, can enhance the brain resilience to cope with the adverse effects of sleep…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.