ERC Advanced Grant · 2022
STEM CELL PLASTICITY IN ADULT NEUROGENIC NICHES
Somatic stem cells (SCs) sustain tissue renewal and regeneration in adult mammals. The maintenance of their stemness and long-lasting preservation in cohabitation with differentiated progeny at specific niches poses these cells to a considerable challenge. To deal with it, SCs display a complex network of yet to be fully uncovered mechanisms that allow multilevel plasticity. Cellular plasticity indicates the ability of cells to reversibly change their phenotype in response to the microenvironment. In the subependymal zone of the adult rodent brain, self-renewing neural SCs (NSCs) generate new neurons for pre-existing olfactory circuits. It is clear that NSCs must be endowed with plasticity…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.