Vries Lab

Research focus

ERC Advanced Grant · 2022

Bioactive lipids Regulate Adaptive Immune responses in Neurodegeneration: novel target for treatment?

Traditionally, AD is regarded as a neurodegenerative disease and as such, the major focus has been on investigating and treating neurodegeneration and neuronal functioning. Only the last decade, it became apparent that AD pathogenesis strongly interferes with immunological processes and vice versa. Indeed, my novel findings show that the immune system in patients with early AD is already severely derailed and highlight a specific role for CD8+ T-cells. My exciting data also suggest the importance of bio-active lipids like sphingolipids and specialized pro-resolving mediators in early AD pathogenesis, possibly by controlling the immune system. The identification of how the altered lipid…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.