Owald Lab

Charite - University Hospital Berlin

Berlin (DE3) · Germany

ERC-funded
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ERC Consolidator Grant · 2022

Simple minds – competition of parallel neural filters in behaviour selection of Drosophila

How we and other animals ‘make up our minds’ is an everlasting question that has occupied philosophers and scientists for centuries. Sensory-evoked activity patterns, memory engrams and internally generated brain activity conveying the animal’s internal state are meant to integrate to promote an appropriate behaviour. Still, direct evidence for how integration works on the network, the neurophysiological and the molecular level remains limited. Exemplifying internal needs with tiredness and hunger, and focusing on the numerically simple brain of Drosophila, we here test a parallel filter hypothesis to explain how sensory and internal states are integrated across the relevant centres of the…

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