ERC Consolidator Grant · 2022
Unravelling the Physiological Roles of GPCR Voltage Dependence
G protein coupled receptors (GPCRs) are broadly expressed in the brain, mediate responses to many molecules, and are crucial for normal brain function and therapeutic intervention. 20 years ago, it was shown that the activity of many GPCRs is regulated by membrane potential. e.g. the activity of cholinergic M2R muscarinic and metabotropic glutamate mGluR3 receptors is reduced by depolarization, and that of M1R and mGluR1a is increased. However, due to high technical challenges, a crucial question remains unanswered: what are the physiological roles of this voltage dependency, its effect on neural activity, or its relevance to behaviour? Recently, we showed that M1R voltage dependence is…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.