ERC Consolidator Grant · 2022
Mechanisms and purpose of top-down neural activity generation across conscious states
Sleep is universal in mammals, yet the origin, structure and purpose of the neural activity patterns which permeate this state remains highly contentious. This is largely because such activity is internally generated and thus not amenable to most traditional methods of analysis. Here I propose top-down circuits in cortical layer 1 as a key site of production and structuring of neural activity during sleep, and detail novel experimental and analysis approaches to probe layer 1 circuits across sleep states at synaptic resolution. Layer 1 of the sensory cortex receives long distance signals from higher cortical regions which during wakefulness powerfully modulate sensory processing, and…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.