ERC Starting Grant · 2022
Cracking the Synaptic Memory Code
Despite their role in long-term information storage, synapses are highly dynamic and composed of rather short-lived components. In the adult mouse brain, it takes a couple of days for half dendritic spines to be replaced. Similarly at the molecular level most synaptic proteins have half-lives in the order of a week meaning they constantly need to be replaced by freshly produced ones. Thus, understanding how long-term memory can arise from unstable elements is one of today’s neuroscience’s greatest challenges. Overturning an old dogma, I discovered using in vivo and in vitro approaches that most synapses produce their own proteins locally at both the pre- and postsynaptic sites.…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.