ERC Advanced Grant · 2023
Septal GABAergic projection neurons are considered “pacemaker” cells as they enable the temporal organization of neuronal spike firing in hippocampal and entorhinal networks that support spatial- and object-coding. Accordingly, medial septum inactivation is associated with cognitive impairments, but the specific role of the septal-entorhinal GABAergic projections therein has remained unexplored. This is a pressing question, as we have evidence that septal GABAergic projections exhibit enhanced vulnerability. In mouse models with neurodegeneration, we found that septal GABAergic axons exhibit signs of degeneration when target cells in the entorhinal cortices are not yet impaired.…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.