ERC Advanced Grant · 2023
Uncovering the cortical cellular basis of specificity and chronicity of pain
Chronic pain remains a fundamental unsolved puzzle in biology and an unmet global challenge in clinical practice. Progress is limited by major gaps in knowledge on neural substrates, owing to overwhelming redundancy of implicated regions and pathways with several pain-unrelated sensory, cognitive and emotional functions as well as lack of understanding on the origins of plasticity and cellular substrates for diverse psychosocial and environmental influences on pain. Here we propose that neocortical neuronal ensembles, i.e., discrete cohorts of co-active neurons intermingled within seemingly redundant pathways, represent a mechanistic correlate for imparting specificity to pain perception,…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.