ERC Advanced Grant · 2023
Molecules for Nociceptor Force Transduction
Pain results from activation of the nociceptive sensory system, which is built upon the primary afferent nociceptor a type of sensory neuron specialized to detect, code and relay information about potentially or actually damaging stimuli. Humans lacking properly functioning nociceptors never experience pain and have reduced life expectancy and suffer severe disability. Nociceptors detect sustained force into ranges that are potentially damaging and sustained nociceptor activation will always lead to pain. It has been assumed that mechanical force transduced by nociceptors requires mechanically activated ion channels in the nociceptor membrane. However, recent data suggests that sensory…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.