ERC Advanced Grant · 2023
Growing Long Distance - RNA Control of Neuronal Extension
Neurons are the longest cells, extending axons over distances that can reach four orders of magnitude larger than their cell body diameters. How can they achieve such long distance growth? After initial engagement with target cells, neurons undergo stretch-induced elongation as the nervous system matures with the growth of the organism. The molecular mechanisms enabling such prodigious growth are unknown. Based on strong preliminary evidence, we tested the hypothesis that both the initial elongating and later stretch-induced axon growth act via a shared RNA localization mechanism. Very strikingly, we identified a specific subset of polyadenylated repeat element RNAs, hereby termed…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.