Paz Lab

Weizmann Institute

- · Israel

ERC-funded
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ERC Advanced Grant · 2023

Modulation of valence-based learning and behavior: a closed-loop approach in the primate amygdala

The primate amygdala is a neural hub that processes computations for learning and memory, specifically when learning involves emotional, motivational, and reinforcement-based signals. This requires it to remain highly adaptive for changes in valence of environments and stimuli. Failures of such computations can lead to maladaptive behaviors and even psychopathologies such as PTSD and Anxiety. However, the core principles of amygdala function continue to elude the field. Recent studies suggest valence is processed in dedicated pathways, and we do not fully understand the mechanisms governing adaptive processing of valence and its reversal. Our overarching goal here is to elucidate the…

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