Wegmann Lab

Research focus

ERC Consolidator Grant · 2023

Tau, a molecular modulator of neuronal energy managment

The intraneuronal somatodendritic "missorting" and aggregation of Tau are pathological hallmarks in neurodegenerative diseases (NDDs) like and Alzheimer's disease (AD), and are thought to be drivers of neurotoxicity. That NDDs manifesting with Tau "missorting" present with (neuro)metabolic abnormalities, often prior to pathology onset, is largely overlooked. EnergizeTau investigates the ground-breaking new idea that the somatodendritic re-sorting of Tau is a physiological response to bioenergetic challenges faced by excitatory neurons, such as hyperexcitation or energy deprivation. In its proposed role as modulator of neuronal energy management, Tau modulates the cellular energy demand…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.