Ratz Lab

Karolinska Institute

Östra Sverige (SE1) · Sweden

ERC-funded
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Research focus

ERC Starting Grant · 2023

Revealing the wiring rules of neural circuit assembly with spatiotemporally resolved molecular connectomics

The human genomeThe human genome contains several thousand genes that play a key role in the development of the brain’s connectome, a precise assembly of neural connections with billions of neurons and trillions of synapses. How is genomic information translated into synapse-specific connectivity underlying behavior and cognition? Answering this fundamental question will provide important insights about the principles underlying nervous system development and is relevant for neurodevelopmental disorders such as autism. However, current approaches to measure neuronal connectivity have intrinsic limitations that prevent combined analysis of connected neurons, and their gene expression…

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