ERC Starting Grant · 2023
Lineage tracing of the human brain
Organisms develop through cell divisions generating clones that progressively organize to form different tissues. This process can be visualized as a cell phylogeny by lineage tracing. In order to track cell lineages, each cell division has to be permanently and uniquely marked. In model systems, this is done by genome editing. In humans this is not applicable, which has historically made impossible to accurately study cell phylogenies. Very recently, however, studies showed that human tissues contain a set of natural markers in the form of somatic DNA variants that permanently and cumulatively label every cell division during development. My work showed that somatic variants are reliable…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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