ERC Starting Grant · 2023
Control of body weight by specialized brain-adipose loop neurons
Disruption of energy homeostasis can lead to obesity, a major health issue worldwide. Therapeutic efforts to reduce adiposity are nullified by metabolic adaptations. The mechanisms underlying these phenomena are unclear, precluding efficient intervention. Although it is well established that important hormonal factors control adiposity, it is less appreciated that fat (white adipose tissue, WAT) is innervated by sympathetic and sensory fibres forming, with discrete brain nuclei, loop circuits. These circuits are well-positioned for enabling WAT-brain bidirectional, non-hormonal communication, yet they remained uncharacterized. This project will uncover the brain circuits processing…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.