Charrier Lab

National Institute of Health and Medical Research (INSERM)

Ile-de-France (FR1) · France

ERC-funded
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Research focus

ERC Consolidator Grant · 2024

Human-specific modifiers of synapses in development, plasticity and disorders

The function of the brain relies on an intricate network of neurons connected by synapses that enable us to feel, think, learn, act, communicate and adapt our behavior to the ever-changing world. Although the molecular composition and organization of synapses are overall conserved across mammals, a large body of evidence indicates that synapses are differentially regulated in humans. This specialization of human synapses is at the heart of what makes us human. It contributes to the increase in connectivity that characterizes the human neocortex. It also extends the period of synaptic maturation during which cognitive and social experiences sculpt developing cortical circuits and many…

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