ERC Consolidator Grant · 2024
Metabolic adaptation in injuries of the peripheral nervous system
The peripheral nervous system constitutes a prime example of a tissue with a strong regenerative potential. Full recovery upon nerve trauma, however, is rare and usually fails in peripheral neuropathies - common, yet largely untreatable neurological disorders. Nerve repair strictly depends on the orchestration of both nerve de- and regeneration by peripheral nerve glial cells, which need to overcome a substantial metabolic challenge in injury. NervAdapt is based on the fundamental premise that Schwann cells, in the course of evolution, developed an exceptional metabolic adaptability to ensure repair. Capitalizing on acute nerve injury as a prototypic model system to explore conserved repair…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.