ERC Consolidator Grant · 2024
Neuronal glycocalyx has been recently recognized as an active agent that contributes to neuronal synapse formation, neuron excitability as well as neuron-autonomous and microglia-dependent brain network remodelling. In particular, the glycan-terminating sialic acids, which often dominate the ends of the chains of glycoproteins and glycolipids on neuronal surface, are required for appropriate brain development and function. Interestingly, almost a fifth of sialic acid biology genes have human-specific changes and aberrant neuronal sialylation and desialylation are implicated in different neurodevelopmental and neuropsychiatric conditions. Thus, I hypothesize than neuronal glycocalyx and…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.