Krabbe Lab

Research focus

ERC Consolidator Grant · 2024

Decoding neuropeptide function in inhibitory amygdala microcircuits

Adaptive behaviour to ever-changing environments is crucial for an animal’s survival in conditions of immediate threat. Meanwhile, there is growing evidence that psychiatric conditions, including anxiety disorders, are at least partly based on maladaptive learning. Neuropeptide signalling plays a key role in regulating synaptic plasticity and hence learning in a state-dependent manner, and dysregulated peptide signalling has been observed in patients suffering from psychiatric disorders. Due to specific expression of peptides and their receptors in distinct cell types and microcircuits, they can contribute to the specificity of neural communication on both temporal and spatial scales.…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.