Gratuze Lab

Research focus

ERC Starting Grant · 2024

Unravelling ApoE4 contribution to tau-mediated synaptic degeneration in AD by combining advanced proteomics and super resolution microscopy

Alzheimer’s disease (AD) is one of the biggest scientific and socio-economic challenges of the 21st century. Currently, there is no cure. Aggregates of amyloid-β and tau protein, along with neuroinflammation/gliosis, are hallmarks of AD that lead to synaptic and neuronal loss as the basis for cognitive decline. The latter correlates closely with the brain distribution of tau aggregates, providing a strong incentive to investigate a link between tau accumulation and synaptic degeneration. Brain apolipoprotein E (ApoE), mainly produced by astrocytes, is essential for lipid transport to neurons and synaptic functions. ApoE4 isoform is the strongest genetic risk factor for AD and contributes to…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.