Koppers Lab

Research focus

ERC Starting Grant · 2024

Decipher how mRNAs are captured at specific subcellular locations to support local translation in neurons

Brain function requires precise regulation of the neuronal proteome which involves localizing thousands of mRNAs to neurites, where specific subsets are translated at the required subcellular locations. Although local translation is well-established, the mechanisms that ensure the capture and translation of specific mRNAs at the correct subcellular location remain elusive. A better understanding of this process is urgent since dysregulation of mRNA localization and translation is emerging as a key pathological event in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). In RNA.ORG, I aim to define, at a molecular level, how the coordination between mRNA transport,…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.