ERC Starting Grant · 2024
Uncovering the molecular mechanisms of oligodendrocyte plasticity in cognitive aging.
Myelin, an oligodendrocyte membrane spirally wrapped around axons, has only recently been appreciated to be a plastic structure, which constantly remodels in response to experience. Myelin plasticity is based on proliferation and maturation of oligodendrocyte precursor cells (OPCs) to form new myelinating oligodendrocytes (oligodendrogenesis), in conjunction with remodelling of myelin that is already established. The cellular and molecular mechanisms governing myelin plasticity and how it contributes to aging-related cognitive decline remain mostly unknown. Whereas cognitive aging is often attributed to neuronal vulnerability, here I propose that early oligodendrocyte dysfunction is a key…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.