ERC Starting Grant · 2024
Dissection of Microglial State Biology in Brain Repair
Microglia, the macrophages of the brain, are critical regulators of many neurobiological functions and implicated by human genetics in several central nervous system diseases. Recent studies have revealed that microglia can adopt distinct co-existing subtypes, termed 'states'. Microglial states appear especially in the context of damage, disease or repair and understanding these states may lead to the ability to precisely modulate neuroinflammation. However, due to a lack of datasets and tools, the dynamics and functions of these microglial states are unknown, representing a poorly explored frontier of neuroscience. The core goal of this proposal is to understand the kinetics and biological…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.