ERC Starting Grant · 2024
Lysosomal exocytosis of metastable proteins to control synaptic function
The extreme length and small caliber of neuronal processes entail complex local regulation of protein turnover. In light of the high metabolic demand and dynamic protein exchange imposed by synaptic neurotransmission, several surveillance mechanisms should be in place to sense protein damage that will otherwise cause synaptic dysfunction. However, it is still essentially unclear how local control of the metastable proteome, whose proteins have a high copy number and are crucial for synaptic function, is accomplished in dendrites to prevent formation of toxic aggregates. My previous work suggests that neuronal activity drives lysosomal fusion with the plasma membrane and exocytotic release…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.