ERC Consolidator Grant · 2025
Mitochondrial Synthesis of Neurotransmitters in Synaptic Function and Memory
Released neurotransmitters must be replenished at extraordinarily fast time scales to support synaptic function, circuit physiology and behavior. However, how axonal metabolism responds to the demands of neuronal activity to preserve neurotransmitter levels remains poorly understood. While our understanding of the biochemical pathways for neurotransmitter synthesis is vastly detailed, very little is known about how these pathways are implemented in mammalian axons to preserve synaptic function and behavior. I hypothesize axonal mitochondria sense neuronal activity and boost their metabolism to provide metabolic precursors that locally replenish glutamate and GABA (γ-aminobutyric acid), the…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.