ERC Consolidator Grant · 2025
Microglia, the brain’s primary macrophages, play essential role in preserving neuronal homeostasis, clearing debris and shaping neural circuits throughout life. These functions are pivotal, particularly in context of aging and neurodegenerative diseases. Human genetic studies implicate microglia in age-related neurodegenerative diseases, with alterations in their endolysosomal network emerging as a critical determinant of disease risk. However, how microglial endolysosomal functions alter during aging and disease remain poorly defined, limiting our understanding of their contribution to disease pathology. This project employs cutting-edge in vivo TurboID proximity labelling proteomics tool…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.