Donato Lab

University of Basel

- · Switzerland

ERC-funded
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ERC Consolidator Grant · 2025

Dissecting the Contributions of Neurogenesis-Defined Subpopulations of Hippocampal Neurons to Balancing Memory Stability and Malleability

The ability to update memories underpins adaptive behaviours, ensuring that our internal models of the world remain consistent with the dynamic environments we inhabit. Striking a balance between memory stability (the persistence and robustness of memories over time) and malleability (the capacity to update memories in response to new information) is thus essential to learn from experience and adapt to change. While the biological foundations of memory stability are increasingly understood, the mechanisms supporting memory malleability – and how they balance with stability – remain largely unknown. What distinguishes a stable memory from a malleable one? What processes govern the updating…

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