ERC Starting Grant · 2025
Quality Control of Damaged Proteins at Synapses
SYNDAM investigates how the brain detects and clears damaged proteins at the primary loci for information transfer and storage— synapses. The synapse expresses many proteins that are mutated or dysregulated in major brain disorders. The information transfer rate at synapses is high and, as a result, synapses are continuously exposed to oxidative challenges that arise from local mitochondrial respiration and oxidase activity. This puts synaptic proteins at risk. This risk is exacerbated by the long lifetimes of neuronal proteins, which prolong their exposure to environmental assaults. It is unclear how this apparent risk is mitigated by protein quality control at synapses— a vital process…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.