ERC Starting Grant · 2025
Shifting from the traditional focus on central nervous system-targeting lymphocytes, MiST-MS posits that glial responses, particularly cellular senescence, are required to compartmentalized self-sustaining chronic inflammation in multiple sclerosis (MS) and related long-term clinical outcomes, including disability. MiST-MS is specifically designed to address the urgent need to identify new therapeutic targets to halt MS clinical progression through two interconnected research lines. The project will first identify cell-specific perturbations and molecular pathways associated with inflammation-driven early brain aging using MS human iPSC-derived microglia and genome-wide CRISPR-Cas9…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.