ERC Consolidator Grant · 2017
Novel Metabolic Pathways in Cancer
Metabolic adaptations in central carbon metabolism play a key role in cancer. Yet, the success of therapeutic interventions in major pathways has been limited, although some of the changes have been known to exist for almost 100 years. Biochemical textbooks present intermediary metabolism as something canonical, and the molecular identity of most enzymes required for the production of known intermediary metabolites is indeed known. Yet, the function of many putative enzymes is still unknown, indicating that novel metabolic pathways containing so far unknown metabolites exist. We have recently discovered a novel metabolic pathway containing two metabolites that have never been described…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.