Rad Lab

Research focus

ERC Consolidator Grant · 2018

Genome-wide surveys and functional analysis of pancreatic cancer metastasis drivers

Metastasis is the major cause of death in pancreatic ductal adenocarcinoma (PDAC). International sequencing efforts on >800 human primaries gave comprehensive insights into PDAC genetics. In contrast, equivalent studies for “metastasis genetics” were not possible, largely because of a lack of metastatic tissue resources, particularly of treatment-naive ones. Another bottleneck is the scarcity of adequate experimental models recapitulating the multi-step nature of metastasis. As a consequence, the molecular basis of metastasis remains poorly understood. We developed unique resources and tools for metastasis research and propose to use them at three levels to systematically interrogate the…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.