ERC Starting Grant · 2018
Regulation of bone metastases by age-associated angiocrine signals
Blood vessels form a versatile transport network and provide inductive signals called angiocrine factors to regulate tissue-specific functions. Blood vessels in bone are heterogeneous with distinct capillary subtypes that exhibit remarkable alterations with age. Bone is the most prevalent site of metastasis, and ageing is linked to the reactivation of dormant tumor cells (dorTCs) and metastatic relapse. Bone remodeling processes are also associated with metastatic relapse. Here, I propose to gain mechanistic insights into the role of blood vessels in regulating bone remodeling. Further, I hypothesize that distinct blood vessel subtypes differentially regulate the fate of disseminated tumor…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.