ERC Advanced Grant · 2020
Cell Plasticity in Metastatic Colorectal Cancer
Colorectal cancer (CRC) belongs to the most frequent tumor entities in both men and women. Although early detection and certain therapies have improved, the prognosis for patients with metastatic diseases is dismal and survival rates are below 10% at 5 years after diagnosis. Colorectal carcinogenesis is greatly dependent on the plasticity of both tumor cells as well as surrounding stromal cells within the tumor microenvironment. Among the latter, both T cells as well as mesenchymal cells substantially contribute to the survival prognosis. Importantly, mesenchymal cells are very heterogenous and various subtypes have been recently described in other tumor entities. Most likely these subtypes…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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