ERC Advanced Grant · 2020
Understanding the Biology of Human Enteroendocrine Cells
Intestinal epithelium consists of self-renewing crypt-villus units and contains 6 mature cell types: Enterocytes, goblet cells, Paneth cells, Tuft cells, M cells and Enteroendocrine cells (EECs). The rare EECs are subclassified by the (>20) hormones they produce. Generally, EECs sense intestinal content and regulate gastrointestinal activity, systemic metabolism and food intake. While one EEC hormone, GLP1, has been developed into a highly successful diabetes drug, a paucity of laboratory models has complicated human EEC studies. Previously, we identified adult crypt stem cells by the novel marker Lgr5, and established conditions to grow ‘gut organoids’ from these. By single cell RNA…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.