ERC Starting Grant · 2020
Thrombotic MEMOry-Linking a break in tolerance to platelets to REthrombosis
ThThrombotic diseases like venous thromboembolism (VTE) are leading causes of mortality worldwide, due to their unpredictable, relapsing occurrence. The strongest predictor of a thrombotic event is a previous thrombosis, implicating that VTE has systemic memory effects beyond local clot formation triggering thrombotic relapse. In T-MEMORE, I will go beyond the state-of-the art of thrombosis research by testing the ground-breaking concept that VTE is not only a local event, but a chronic, systemic disease caused by an immune response to platelets mimicking a break in tolerance. My recent research revealed that venous thrombosis is the outcome of a sterile inflammation primarily directed…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.