ERC Starting Grant · 2020
Deciphering sex differences in the human immune system
Women face a four-fold higher risk of developing an autoimmune disease compared to men. Sex differences in immune-mediated disorders are well-documented, but have remained poorly understood and are not taken into account in current therapies. To improve treatment of sex-biased autoimmune disorders I believe it will be essential to gain a much deeper understanding of fundamental factors controlling sex differences in the human immune system. The present proposal applies two uniquely informative human model systems to determine the separate roles of sex hormones and sex chromosomes in immune regulation. First we will investigate how the immune system is transformed during female-to-male and…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.